Tumor Targeting by Monoclonal Antibody Functionalized Magnetic Nanoparticles

Development of tumor targeting bioprobes ((111)In-chimeric L6 monoclonal antibody nanoparticles) for alternating magnetic field cancer therapy.

OBJECTIVES (111)In-chimeric L6 (ChL6) monoclonal antibody (mAb)-linked iron oxide nanoparticle (bioprobes) pharmacokinetics, tumor uptake, and the therapeutic effect of inductively heating these bioprobes by externally applied alternating magnetic field (AMF) were studied in athymic mice bearing human breast cancer HBT 3477 xenografts. Tumor cell radioimmunotargeting of the bioprobes and therap...

Functionalized Magnetic Nanoparticles for Selective Targeting of Cells

Magnetic metal oxide nanoparticles were conjugated to single stranded DNA (ssDNA), and Cytosin-phosphatidyl-Guanosin oligonucleotide (CpG ODN) to detect and activate Toll-like (TLR9) receptors in cells and to follow nanoparticle cellular trafficking by different ways of imaging while at the same time serving as a drug carrier system. By virtue of their magnetic properties these nanoparticles ma...

Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes.

UNLABELLED Single-walled carbon nanotubes (CNT) are mechanically robust graphene cylinders with a high aspect ratio that are comprised of sp(2)-bonded carbon atoms and possessing highly regular structures with defined periodicity. CNT exhibit unique mechanochemical properties that can be exploited for the development of novel drug delivery platforms. We hypothesized that novel prototype nanostr...

Antibody Distribution on Bio-Functionalized Magnetic Nanoparticles Analyzed by Spatial-Resolved EELS

A Tumor-specific MicroRNA Recognition System Facilitates the Accurate Targeting to Tumor Cells by Magnetic Nanoparticles

Targeted therapy for cancer is a research area of great interest, and magnetic nanoparticles (MNPs) show great potential as targeted carriers for therapeutics. One important class of cancer biomarkers is microRNAs (miRNAs), which play a significant role in tumor initiation and progression. In this study, a cascade recognition system containing multiple plasmids, including a Tet activator, a lac...